WHAT YOU NEED TO KNOW ABOUT DHEA

DHEA Dosage and Delivery System Critical for Effectiveness!

DHEA (dehydroepiandrosterone) is a plentiful but only vaguely understood steroid-like substance secreted by the adrenal cortex. It circulates in the bloodstream in quantities thousands of times greater than the sex hormones, estrogen and testosterone. All of the specific roles of this substance in the body are not yet conclusively known.

DHEA is structurally similar to other steroid homones (such as estrogen, progesterone, and testosterone) but it possesses its own spectrum of biological effects. DHEA can be converted into other hormones, including estrogen, testosterone and cortisone, but it is not merely a "buffer hormone," a reservoir which the adrenals could draw upon to produce more of these other hormones. Scientists have shown that cells contain specific DHEA receptors the sole function of which is to bind DHEA. This demonstrates that DHEA is more than just a buffer hormone and that it has functions of its own in the body.

More Than 90 percent of DHEA is converted to DHEA sulfate (DHEA-S) prior to circulation. DHEA-S may convert back to DHEA, convert to other hormones, or stimulate the production of other hormones by the ovaries, testes, etc. DHEA and DHEA-S are, for the most part, functionally interchangeable. There are some significant differences, which will be noted later.

DHEA exists in the body in higher quantities than any other hormone. Levels in the body peak around age 21 and slowly decline over the years. DHEA production can decrease 80-90 percent by the age of 75.

It is known that DHEA converts to or stimulates the production of estrogens, testosterone, progesterone, cortisone, and the many other steroid hormones as the body needs them. In a sense, DHEA, as a pre-hormone, can be called the "mother hormone." It also acts as a buffer hormone that interacts with other hormones.

DHEA is found in the brain at high concentrations. Many of its effects are related to the nervous system of which the brain is the core. This would lead us to believe that DHEA and at least some of the brain functions are closely correlated.

Abnormal patterns of DHEA in the body accompany and often underlie several disease states and dysfunction.

DHEA converts to or stimulates the production of estrogens, testosterone, progesterone, cortisone, and many other steroid hormones as the body needs them.

Levels of DHEA production in the body vary according to stress, fever, sudden low blood sugar, and disease states. DHEA levels are lower among smokers than among nonsmokers, and lower among heavy drinkers than among non-drinkers. Birth control pills and other synthetic hormones also deplete DHEA.

Levels of salivary steroids accurately reflect fluctuating DHEA levels in the body. Salivary DHEA concentration is about 0.1 percent of its plasma concentration.

Men produce about 31 mg DHEA daily, women, about 19 mg.

DHEA has a half-life of 8-11 hours.

DHEA is found in the brain in very high concentrations equal to that in the adrenal cortex.

Abnormal patterns of DHEA accompany and often underlie several disease states and dysfunction.

Supplements include DHEA-S, which requires a prescription, and free form DHEA that is available over the counter.

DHEA is a mother load of some 10 different steroidal hormones associated with youth. We all know that with increasing age women suffer from decreased estrogen production and men from decreased testosterone production. Hormone Replacement Therapy (HRP), providing synthetic estrogen to women and synthetic testosterone to men seems to help alleviate some of the problems associated with aging. Because there are so many different hormones circulating about the body, supplementation of just one or two hormones causes an imbalance and side effects can occur.

While estrogen has shown to have beneficial cardiovascular effects progestins exert a detrimental effect on blood lipids by increasing LDL and reducing HDL cholesterol. Without progestin, prolonged estrogen therapy increases the risk of endometrial cancer. In summary, balance of all circulating hormones is the key. In the long run, imbalance promotes sickness and aging.

DHEA provides an alternative pathway to the gonadal hormones such as testosterone, estrogens and also cortisone. It is necessary for at least 18 different steroidal hormones. It is self regulating. Only those hormones needed are produced.

In addition to its precursor function in the formation of testosterone and estrogens, supplemental DHEA has been shown to lessen many age related symptoms in both human and animal studies and it dramatically extends life spans of rodents. This may be in part due to its effects on hormone syntheses but DHEA also has additional biologic properties.

DHEA is under close scrutiny as an anti-obesity treatment in women and for its anti-cancer influences.

In the body, DHEA has action through the steroids it creates and also directly through its own cellular receptors.

DHEA effects the entire endocrine system by regulation through enzyme inhibition or activation. This means, it can stimulate the production of other hormones, of most significance, estrogen by the ovaries and testosterone by the testicles.

DHEA is converted into other hormones by the body and therefore acts as a precursor or a pro-hormone. DHEA has been called a "buffer hormone" that interacts with other hormones. DHEA gives rise to the sex steroids as well as additional hormones, which have a wide variety of physiologic functions. If the levels of a particular sex hormone are low, DHEA can stimulate its production through either the appropriate gland (ovaries or testes) or through biosynthesis.

The varied action of this hormone is based upon the particular physiologic setting of the individual. DHEA appears to work in widely divergent systems against a variety of targets, depending on the state of the host.

* Regulates hormones through specific or non-specific hormone receptors.

* Inhibits an antiproliferative enzyme, G-6-PD.

* Increases fat metabolism through thermogenesis.

* Decreases desire to eat, possibly through it effects on insulin.

* Decreases stress reaction.

* Stimulates T-lymphocytes / Enhances interleukin 2 production.

* Anti-osteoporosis / Improves calcium absorption.

* Anti-inflammatory.

Adrenal corticotropic hormones (ACTH) and other non ACTH regulatory components control adrenal steroid secretion. External factors such as stress and illness play significant roles in determining output (57 percent reduction in DHEA levels following ACTH stimulus due to chronic stress, 77 percent reduction due to chronic illness).

Genetics: About 65 percent of production is related to heredity.

24-hour Circadian Variation: Account for daily fluctuations of 13 percent.

Seasonal Circadian Variation: An increase in plasma concentrations of DHEA can be seen during the winter months.

Age: Levels of DHEA production increase through puberty, peaking between age 20 and 25. After this time production slowly diminishes.

Exercise: Strenuous exercise such as running, swimming, football, weight lifting, etc. Increases serum concentrations of cortisol and DHEA in both men and women. In contrast, marathon runners (1100Km for 20 days) show no change in DHEA and a return to normal cortisol levels after completion of a 24-40-week training program.

Hypertension: DHEA excretion rates through the urine were significantly decreased by 85-95 percent below controls in clinically hypertensive patients. Further patients. Further investigation revealed that circulating DHEA levels were not different in hypertensive individuals when compared to their age matched control.

Emotional Stress: Stressful events such as anticipated death or surgery of a family member, hospital admission, public speaking, mental performance testing, residence relocation in the elderly, depress DHEA production. The Cortisol/DHEA ratio in individuals with panic disorder is depressed by about 50 percent.

Obesity: The cortisol secretion rate is increased in obese individuals. Production rates of DHEA are higher than normal in obese individuals. However, circulating DHEA levels remain unchanged due to an accelerated metabolic clearance rate.

Diversion of the precursors for both cortisol and adrenal androgens reduces DHEA output. This may be due to nutritional factors, stress, illness, chemical alteration through drugs, etc. Cholesterol is one of the precursors for DHEA.

Diet: Vegetarian diets and the intake of saturated and unsaturated fats do not significantly effect DHEA levels. However, decreases in other steroids such as Androstenedione, extrone and estradiol have been reported.

Drugs: A number of drugs, not only pharmaceuticals, but also alcohol and tobacco, lower levels of DHEA, probably due to the increased stress on the body. Intake of synthetic steroid hormones also lowers DHEA levels. Birth control pills especially have a detrimental effect.

Both our physical and emotional health is adversely affected by stress. Because stress cannot be completely eliminated, we must learn how to guard our bodies and minds against the harmful effects of stress.

While DHEA "anti-aging" products have flooded the marketplace in the last few months, few people realize that taking encapsulated DHEA is the least effective means to raise DHEA levels. Only about 50% of the DHEA in capsules or tablets taken orally is actually absorbed and utilized. Individuals with health problems such as osteoporosis, cancer, Alzheimer's, heart disease, arthritis, lupus, diabetes, etc., who have particularly low DHEA levels, tend to have an even lower absorption rate.

Liquid sublinguals: Provide the highest and most rapid rate of absorption at 95-99%. DHEA directly enters the bloodstream, eliminating liver first pass. DHEA Sublingual provides users almost instant absorption with 5 mg. DHEA per drop under the tongue. Sublinguals, taken in the proper dosage, are highly effective for individuals suffering from acute inflammatory conditions such as arthritis, allergies, asthma, sinusitis, and lupus.

*Pure Pharmaceutical Grade DHEA Sublingual.

*Pure Pharmaceutical Grade DHEA Skin Cream.

Creams: Provide absorption from 50 to 85%. The variance depends on the quality of the cream, presence of carrier agents, location of application (thin skin or fatty areas), cleanliness of skin and humidity.

The benefits of topical DHEA reach beyond those of oral consumption. Frs. Arthur G. Schwartz and Laura Pashko reported that topical application of DHEA on mouse skin inhibits skin tumor promotion. "Cancer Prevention and DHEA" published by the New York Academy of Sciences (1996) pages 180-186.

Capsules: Provide absorption of about 50%. Depending on the flow agent used, and health of the individual, absorption rates may be even lower. We suggest the superior flow agent microcystalline cellulose, for optimal DHEA usage. For better results individuals may open the capsule, and place the contents under the tongue.

In the prime of life, men produce about 31 mg. of DHEA daily, women about 19 mg. Production levels start to decline around age 25 or 30. By age 90 the body only produces about 5% of what it did at age 20. Health problems are associated with low levels of DHEA.

*Pure Pharmaceutical Grade DHEA Capsules.

*Pure Pharmaceutical Grade PREGNENOLONE Capsules.

Optimal dosage depends on one's age and state of health. Healthy individuals over 40 should supplement their own production level to total 19 mg. in women or 31 mg. in men. Therapeutic dosages (recommended ONLY to treat specific medical problems, and with doctor's approval), start around 200 mg. daily (encapsulated). Less may be needed when using a liquid sublingual because of the higher absorption rate. DHEA half life is relatively short, about 10 hours. For optimal dosage, supplement half, twice daily (every 12 hours) to maintain even levels throughout each 24 hour period.

Occasional side-effects, (seldom experienced except at higher therapeutic dosages), can include acne, unwanted hair growth, chest tightness, heart palpitations, sleeplessness, irritability, and fatigue. If these are experienced the dosage is too high and should be reduced. Side effects should subside in 24 hours. Taken at the proper dosage level there are NO known long term adverse effects to taking DHEA. DHEA Supplementation is contraindicated for men with existing prostate problems.

OR

Click On Buttons Below For More Information

***Be alert to what you are purchasing. There is a great deal of difference between yam tablets with no usable DHEA, and pure pharmaceutical grade DHEA that is sold here. Although DHEA is generally recognized as safe and without significant side-effects for most individuals, we are all unique. Pay attention to your own bodily system; it is the best and final judge of any supplementation program. It is important to follow the recommended dosage on the bottle; begin with small doses and if you have any problems, CONSULT YOUR PHYSICIAN.

***Disclaimer: The nutritive value of these substances has not been established. These products make
no claim to having a disease related benefit or any relationship to a health related condition. Always
consult a physician before taking any supplements. The statements presented here have not been
evaluated by the Food and Drug Administration, nor is it required by law. These products are not
intended to diagnose, treat, cure or prevent any disease. All of the above information has been provided
by the manufacturer. RDS has not conducted any independent testing on these products.

*Pure Pharmaceutical Grade DHEA Sublingual.

*Pure Pharmaceutical Grade DHEA Skin Cream.

*Pure Pharmaceutical Grade DHEA Capsules.

*Pure Pharmaceutical Grade PREGNENOLONE Capsules.

Resource Development Specialists
PO Box 821
Muskogee, OK 74402
PHONE: (918) 348-2439
Email: Resource Development Specialists

HOME